阐明宿主肠道内微生物群衍生分子的功能对于理解人类与其微生物群之间的共生关系非常重要。为什么动物肠道需要微生物呢？本课题组以线虫为模式生物，建立了宿主和微生物的筛选体系，发现：

1）肠道微生物次级代谢产物enterobactin(肠杆菌素)促进宿主对铁的吸收和利用(Cell，2018)

2）肠道微生物次级代谢产物维生素B2调控宿主肠道蛋白酶活性，从而促进动物对食物的利用(eLife, 2017)。

今后，课题组将以线虫、无菌小鼠为模式生物，重点研究以下问题：

欢迎本科生，博士后加入我们的团队，共同探索未知的领域。且欢迎广大科研爱好者来实验室交流，学习，访问，合作。

邮箱：qibinlab@163.com 

1. An unexpected benefit from E. coli: how enterobactin benefits host health.

Sewell AK, Han M, Qi B.

Microb Cell. 2018 Sep 27;5(10):469-471. doi: 10.15698/mic2018.10.653. (Cover)

2. Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.

Qi B, Han M.

Cell. 2018 Oct 4;175(2):571-582.e11. doi: 10.1016/j.cell.2018.07.032. Epub 2018 Aug 23.

(Accompanied by a Preview by Dennis H. Kim, Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth. Cell, 175 (2) p311-312 DOI: https://doi.org/10.1016/j.cell.2018.09.020)

(Reviewed by  Gregory J. Anderson, Iron Wars — The Host Strikes Back. The New England Journal of Medicine.  2018; 379:2078-2080  

DOI: 10.1056/NEJMcibr1811314 )

Reported by many US and international news outlets:

Popular Science: https://www.popsci.com/gut-microbiome-iron

Denver Post: https://www.denverpost.com/2018/08/23/e-coli-health-benefits-cu-boulder/

Infectious Diseases Hub: https://www.id-hub.com/2018/08/23/e-coli-helpful-bacterium/

Daily Mail/UK: https://www.dailymail.co.uk/health/article-6091083/E-coli-used-drugs-treat-anemia.html

Times of India: https://timesofindia.indiatimes.com/home/science/how-e-coli-could-aid-in-fight-against-anaemia/articleshow/65530599.cms

新华社：http://www.xinhuanet.com/politics/2018-08/25/c_1123327494.htm

3. A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal's food behavior and growth.

Qi B, Kniazeva M, Han M.

Elife. 2017 Jun 1;6. pii: e26243. doi: 10.7554/eLife.26243.

4. EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling.

Zhang F#, Qi B#, Wang L#, Zhao B, Rode S, Riggan ND, Ecker JR, Qiao H. (#co-first author) 

Nat Commun. 2016 Oct 3;7:13018. doi: 10.1038/ncomms13018.

5. Modulation of root-skewing responses by KNAT1 in Arabidopsis thaliana.

Qi B, Zheng H.

Plant J. 2013 Nov;76(3):380-92. doi: 10.1111/tpj.12295. Epub 2013 Aug 24.

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邮箱：qibinlab@163.com