1. 长链非编码RNA参与转录和转录后调控的分子机理

2. 转录过程中大分子蛋白复合体的动态调节机制

3. RNA结合蛋白复合体中RNA在转录和翻译过程中的作用机理和对疾病的影响

4. 寡聚核苷酸药物作用机理和开发

1. Lai F, Damle S, Ling KK, Rigo F. Directed RNase H cleavage of nascent transcripts causes transcription termination. Molecular Cell (2020)，77(5): 1032-1043 (first and co-corresponding author)

2. Yue J#, Lai F#, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes & Development (2017), 31(17): 1809-1820 (Co-first author)

3. Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F*, Shiekhattar R*, Chen JF*. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances (2016) 2:2(9):e1601167 (Co-corresponding author)

4. Lai F, Gardini A, Zhang A, Shiekhattar R. Integrator mediates the biogenesis of enhancer RNAs. Nature (2015) 525: 399-403;

5. Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013), 494: 497-501

6. Lai F, Thacker J, Li Y, and Doerner P. Cell division activity determines the magnitude of phosphate starvation responses in Arabidopsis. Plant J. 2007 May, 50(3) 545-556 (Cover)

7. Lai F, Blumenthal E, Shiekhattar R. Detection and Analysis of Long Noncoding RNAs. Methods in Enzymology. 2016 Mar. 28th.

8. Lai F, Shiekhattar R. Enhancer RNAs: the new molecules of transcription. Curr Opin Genet & Dev. 2014 Apr, 25: 38-42; 

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