2007年于英国爱丁堡大学获得博士学位。2007-2019年先后在西班牙巴塞罗那CRG、美国费城Wistar Institute、迈阿密大学癌症中心从事转录和转录后调控的分子机制研究。2020年作为威尼斯欢乐娱人城AⅤ大中国杰出人才引进，加入威尼斯欢乐娱人城AⅤ大中国任研究员。

生信专业招收方向

1.各种高通量测序结果的生信分析方法

2.应用生物信息学手段研究寡聚核苷酸药物作用的分子机制

代表性文章

1.Lai F, Damle S, Ling KK, Rigo F. Directed RNase H cleavage of nascent transcripts causes transcription termination. Molecular Cell (2020)，77(5): 1032-1043

2.Yue J#, Lai F#, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes & Development (2017), 31(17): 1809-1820

3.Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F*, Shiekhattar R*, Chen JF*. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Science Advances (2016) 2:2(9): e1601167

4.Lai F, Gardini A, Zhang A, Shiekhattar R. Integrator mediates the biogenesis of enhancer RNAs. Nature (2015) 525: 399-403;

5.Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013), 494: 497-501

6.Lai F, Thacker J, Li Y, and Doerner P. Cell division activity determines the magnitude of phosphate starvation responses in Arabidopsis. Plant J. 2007, 50(3) 545-556 (Cover)

7.Lai F, Blumenthal E, Shiekhattar R. Detection and Analysis of Long Noncoding RNAs. Methods in Enzymology. 2016 Mar. 28th.

8.Lai F, Shiekhattar R. Enhancer RNAs: the new molecules of transcription. Curr Opin Genet & Dev. 2014 Apr, 25: 38-42;